Click the link below to go through this must-read article on the latest COVID-19 research on drugs/vaccines published in Clinical Trials Arena
Coronavirus treatment: Vaccines/drugs in the pipeline for COVID-19
As a new strain of deadly coronavirus infecting lakhs in China crosses international borders into the US, this outbreak begs the question: how do you treat coronavirus? Even as US President Donald Trump requested Prime Minister Narendra Modi to release the anti-malarial drug hydroxychloroquine to treat COVID-19 patients, the decades old malaria-drug appears to have some good results in the treatment of coronavirus patients. Trump said that it looked as if hydroxychloroquine is having some good results.
On March 31, the Indian
Union Health Ministry had recommended the use of hydroxychloroquine, in
combination with azithromycin, on those severely suffering from COVID-19 who
require ICU management. In its revised guidelines on the 'Clinical Management
of COVID-19, the ministry said the drug is presently not recommended for
children aged less than 12 and pregnant and lactating women. The ICMR has also
repeatedly stressed and conveyed that the drug is not recommended to be used by
everyone.
Currently, however, there is no cure for this coronavirus, and treatments are based on the kind of care given for influenza (seasonal flu) and other severe respiratory illnesses, known as "supportive care," according to the Centers for Disease Control and Prevention (CDC). These treatments essentially treat the symptoms, which often in the case of COVID-19 involve fever, cough and shortness of breath. In mild cases, this might simply mean rest and fever-reducing medications such as acetaminophen (Tylenol) for comfort.
In hospitals, doctors and nurses are sometimes treating COVID-19 patients with the antiviral drug oseltamivir, or Tamiflu, which seems to suppress the virus' reproduction in at least some cases. This is somewhat surprising, Michigan Tech virologist Ebenezer Tumban told Live Science, as Tamiflu was designed to target an enzyme on the influenza virus, not on coronaviruses. The National Institutes of Health has begun a clinical trial at the University of Nebraska Medical Center to test the antiviral remdesivir for COVID-19, the agency announced Feb. 25. In China, doctors are also testing an array of other antivirals originally designed to treat Ebola and HIV, Nature Biotechnology reported.
In cases in which pneumonia inhibits breathing, treatment
involves ventilation with oxygen. Ventilators blow air into the lungs through a
mask or a tube inserted directly into the windpipe. A New England Journal of
Medicine study of 1,099 hospitalized patients with the coronavirus in China
found that 41.3% needed supplemental oxygen and 2.3% needed invasive mechanical
ventilation. Glucocorticoids were given to 18.6% of patients, a treatment often
used to reduce inflammation and help open airways during respiratory disease.
A team of Australian researchers say they’ve found a cure for the novel coronavirus and hope to have patients enrolled in a nationwide trial by the end of the month. One of the two medications is a HIV drug, which has been superseded by “newer generation” HIV drugs, and the other is an anti-malaria drug called chloroquine which is rarely used and “kept on the shelf now” due to resistance to malaria. He said the researchers want to study them in a “very meaningful way” against the coronavirus to “try and alleviate that anxiety of Australians”.
Meanwhile, a Siddha doctor from Tamil Nadu has claimed to have formulated a herbal medicine that can cure Coronavirus, which was first detected in the city of Wuhan in China in December 2019 and has no effective vaccine or drug to treat it. Dr Thanikasalam Veni of Rathna Siddha Hospital in Chennai has 25-year of vast experience in field Siddha and Ayurvedic medicines."We want to tell the World Health Organisation (WHO) and the Chinese government that our medicine is very effective in treating multi-organ failure in corona fever condition," he said. The Siddha doctor claimed that the medicine formulated by him along with his team treats infections caused by the virus within 24 hours to 40 hours.
Infected patients should treat symptoms the same way they would a cold -- with rest, pain or fever medication and plenty of fluids. Common signs of infection include respiratory symptoms, fever, cough, shortness of breath and breathing difficulties. In more severe cases, the infection can cause pneumonia, severe acute respiratory syndrome, kidney failure, and even death.
SOURCES:
https://www.khaleejtimes.com/international/india/Coronavirus-Indian-doctor-claims-to-have-found-medicinal-cure-for-deadly-nCoV--
https://www.theweek.in/news/world/2020/04/05/trump-requests-modi-to-release-anti-malarial-drug-for-covid-19-treatment.html
https://www.foxnews.com/health/coronavirus-treatment
https://www.news.com.au/lifestyle/health/health-problems/coronavirus-australia-queensland-researchers-find-cure-want-drug-trial/news-story/93e7656da0cff4fc4d2c5e51706accb5
https://www.livescience.com/can-coronavirus-be-cured.html
Coronavirus treatment: Vaccines/drugs in the pipeline for COVID-19
As a new strain of deadly coronavirus infecting lakhs in China crosses international borders into the US, this outbreak begs the question: how do you treat coronavirus? Even as US President Donald Trump requested Prime Minister Narendra Modi to release the anti-malarial drug hydroxychloroquine to treat COVID-19 patients, the decades old malaria-drug appears to have some good results in the treatment of coronavirus patients. Trump said that it looked as if hydroxychloroquine is having some good results.
Currently, however, there is no cure for this coronavirus, and treatments are based on the kind of care given for influenza (seasonal flu) and other severe respiratory illnesses, known as "supportive care," according to the Centers for Disease Control and Prevention (CDC). These treatments essentially treat the symptoms, which often in the case of COVID-19 involve fever, cough and shortness of breath. In mild cases, this might simply mean rest and fever-reducing medications such as acetaminophen (Tylenol) for comfort.
In hospitals, doctors and nurses are sometimes treating COVID-19 patients with the antiviral drug oseltamivir, or Tamiflu, which seems to suppress the virus' reproduction in at least some cases. This is somewhat surprising, Michigan Tech virologist Ebenezer Tumban told Live Science, as Tamiflu was designed to target an enzyme on the influenza virus, not on coronaviruses. The National Institutes of Health has begun a clinical trial at the University of Nebraska Medical Center to test the antiviral remdesivir for COVID-19, the agency announced Feb. 25. In China, doctors are also testing an array of other antivirals originally designed to treat Ebola and HIV, Nature Biotechnology reported.
A team of Australian researchers say they’ve found a cure for the novel coronavirus and hope to have patients enrolled in a nationwide trial by the end of the month. One of the two medications is a HIV drug, which has been superseded by “newer generation” HIV drugs, and the other is an anti-malaria drug called chloroquine which is rarely used and “kept on the shelf now” due to resistance to malaria. He said the researchers want to study them in a “very meaningful way” against the coronavirus to “try and alleviate that anxiety of Australians”.
Meanwhile, a Siddha doctor from Tamil Nadu has claimed to have formulated a herbal medicine that can cure Coronavirus, which was first detected in the city of Wuhan in China in December 2019 and has no effective vaccine or drug to treat it. Dr Thanikasalam Veni of Rathna Siddha Hospital in Chennai has 25-year of vast experience in field Siddha and Ayurvedic medicines."We want to tell the World Health Organisation (WHO) and the Chinese government that our medicine is very effective in treating multi-organ failure in corona fever condition," he said. The Siddha doctor claimed that the medicine formulated by him along with his team treats infections caused by the virus within 24 hours to 40 hours.
Infected patients should treat symptoms the same way they would a cold -- with rest, pain or fever medication and plenty of fluids. Common signs of infection include respiratory symptoms, fever, cough, shortness of breath and breathing difficulties. In more severe cases, the infection can cause pneumonia, severe acute respiratory syndrome, kidney failure, and even death.
SOURCES:
https://www.khaleejtimes.com/international/india/Coronavirus-Indian-doctor-claims-to-have-found-medicinal-cure-for-deadly-nCoV--
https://www.theweek.in/news/world/2020/04/05/trump-requests-modi-to-release-anti-malarial-drug-for-covid-19-treatment.html
https://www.foxnews.com/health/coronavirus-treatment
https://www.news.com.au/lifestyle/health/health-problems/coronavirus-australia-queensland-researchers-find-cure-want-drug-trial/news-story/93e7656da0cff4fc4d2c5e51706accb5
https://www.livescience.com/can-coronavirus-be-cured.html
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